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Erratum in Cancer Res. Clinical trials have proven oncolytic virotherapy to be safe but not effective. However, it is unclear whether these cells directly impede intratumoral persistence of OV through phagocytosis and whether they infiltrate the tumor from the blood or the brain parenchyma. To investigate this, we depleted phagocytes with clodronate liposomes CL in vivo through systemic delivery and ex vivo in brain slice models with gliomas. Intratumoral viral titers increased 5-fold.